Endocrine Abstracts

Background and aim: C-reactive protein (CRP) is a sensitive marker for systemic inflammation. In this study we aimed to investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and BMI, body fat mass and fat distribution in healthy subjects.Subjects and methods: A total 117 healthy subjects aged with 20–68 yr [normal weight (BMI 18.5–25.0 kg/m2, n:35), overweight (BMI: 25–30 kg/m2</sup...

Background and aim: Carotid intima-media thickness (IMT), as assessed by B-mode ultrasound, is a commonly used clinical marker that reflects systemic burden of atherosclerosis and value of IMT at or above 1 mm at any age is associated with a significantly increased risk of myocardial infarction. On the basis of such findings, we aimed to clarify the relationship between carotid intima-media thickness and anthropometric and metabolic parameters in virtually healthy subjects.</p...

Background and aim: Somatostatin analogues such as octreotide acetate were used in acromegalic patients as primary or secondary treatment. In this study we aimed to report completely disappearing of adenoma and clinical cure in 3 acromegalic cases that rejected surgical treatment.Case1: E.A (62 years old, female) She reported enlargement of his hands, deepening of his voice and increases in shoe size. MRI revealed a macro adenoma which was spread to cave...

Using pharmacological chaperones is one of the most common area to rescue trapped proteins from Endoplasmic reticulum (ER) or Golgi apparatus as therapeutic targets in research of some endocrine disorders. Diabetes insipidus is one of these disorders and AVPR2 is seen mostly mutated in hereditary type of the disorder. As proteins go through a journey from ribosome till the place where they function at, AVPR2 also tracks the same way as a G-protein coupled receptor. A mutation ...

Nefrojenic Diabetes insipidus is one of the typical conformational disorders result from protein misfolding and degredation or aggregation due to the mutations in AVPR2. The patients of nephrogenic Diabetes insipidus have difficulty in concentrate of urine and because of this, they have polyuria, hypoosmolar urine and hypernatremia in variable levels. To make them relieved, many treatment strategies have been studying and using dDAVP nasally is one of these strategies. Another...

Aim: Neopterin has been found to be associated with disease activity in various infectious, inflammatory, and autoimmune diseases. It is an indicator of immune response as it is released after activation of monocytes and macrophages by IFN-γ. It was aimed to measure neopterin levels in Graves’ disease, which is a T cell-mediated autoimmune disease of the thyroid gland.Materials and Methods: Twelve healthy individuals (6 women, 6 men), 13 Graves...

Objective: Migraine is a common primary headache disorder that affects 12-15% of the general population. Also, vitamin D deficiency is a global health problem. A few studies have shown relationship between serum vitamin D levels and headache. The aim of this study was to investigate the difference in serum levels of 25-Hdroxy vitamin d [25(OH)D] between migraine patients and healthy controls and also to determine the relationship of vitamin D deficiency with frequency and seve...

Cortex protecting surgery for bilateral pheochromocytoma protects the patient from adrenal insufficiency. Risk of relapse is low. 35 years old woman had paroxysmal seizures and hypertension crises for the last year which became more frequent in the last 10 days. She had thyroidectomy and under the use of levothyroxine the patient. Because of a nodule on ultrasonography and paternal history of MEN 2A which led to a check of calcitonin level that resulted 8 times higher than the...

Although primary hyperparathyroidism (PHPT) is seen in young women at 8/million ratio, it is more rare to be seen with pregnancy. If diagnosed and not treated during pregnancy, the mother may have nephrolithiasis, hypercalcemic crisis, hypertension, preeclampsia, pancreatitis, death and intrauterine growth retardation in the fetus, low birth weight, preterm delivery, intrauterine death or postpartum tetany. Forty-year-old woman at the 14th week of gestation was diagnosed with ...

Introduction: IgG4-dependent disease is a newly defined fibroinflammatory disease. This disease has been shown to affect almost all organs in the body, especially the pancreas, salivary gland, orbital tissue, lymph node, lung and kidney. IgG4 hypophysitis is a rare and inflammatory process that mimics pituitary tumors. The diagnosis of IgG4 releated hypophysitis can be done in many ways. The definitive diagnosis is biopsy; however, it is not necessary in most cases. If the oth...